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Cantharidin (YCANTH™) is a proprietary drug-device combination product containing a formulation of cantharidin 0 7% topical solution (a vesicant naturally derived from blister beetles) delivered via a single-use applicator that has been developed by Verrica Pharmaceuticals Inc for the treatment of molluscum contagiosum and is also being developed for the treatment of warts In July 2023 In the Middle Ages, in Europe, the dried bodies of the ‘Spanish fly’ (Lytta vesicatoria), a green, 11- to 21-mm-long beetle that can be found in certain areas of Europe and some eastern regions such as Vietnam, Taiwan, Thailand, Korea, and China, began to be used as an alleged aphrodisiac and abortifacient and in the treatment for malignant tumors as an extended application in the Chinese Cantharidin , or exo,exo-2,3-dimethyl-7-oxabicyclo[2 2 1]heptane-2,3-dicarboxylic acid anhydride 1, is a monoterpene stored in the insects' blood It is stable and remains toxic even in beetle carcasses for long periods of time, being classified as a strong vesicant substance that causes blisters on contact with the human skin, giving the fly Cantharidin is a vesicant produced by beetles belonging to the order of Coleoptera and the family of Meloidae 1 There are currently more than 1500 species of cantharidin -producing beetles 2 Commonly known as blister beetles or Spanish fly, they are variable in color, measure up to 2 5 cm in length, 3 and do not bite or sting 1 Epicauta Since NAC reduced cantharidin-induced ROS production, an MTT assay was performed for further confirming whether the cantharidin-induced growth inhibition could also be attenuated by NAC Treatment with 10 μ m cantharidin markedly inhibited cellular growth, while pretreatment with NAC showed no significant protective function against the antitumor effect of cantharidin ( Fig 4c,d ) What is cantharidin 1% podophyllin 2% salicylic acid 30% solution? onlinelibrary wiley com doi 10 1111 cbdd 12180Norcantharidin (NCTD) is the demethylated analog of cantharidin, with allegedly reduced toxicity However, there is still limited information regarding its posology and potential risk in its use in cancer treatment Healthy BDF1 mice were intraperitoneally administered with norcantharidin (0, 3, 6, 12, and 25 mg kg) every 24 h for 6 days Survivor mice were euthanized, and the brain, lungs jamanetwork com journals jamadermatology fullarticle 478535onlinelibrary wiley com doi 10 1111 j 1349-7006 2010 01523 xIn blister beetle …that secrete an irritating substance, cantharidin , which is collected mainly from Mylabris and the European species Lytta vesicatoria, commonly called Spanish fly Cantharidin is used medically as a topical skin irritant to remove warts link springer com article 10 1007 s40257-018-0375-4What is cantharidin used for? Nov 25, 2023 · Cantharidin 0 7% topical solution is for topical use only and is not for oral, mucosal, or ophthalmic use A single application of cantharidin topical solution 0 7% is applied directly to each molluscum contagiosum lesion every 3 weeks as needed Cantharidin is a defensive terpenoid found in blister beetles 1,2,3,4,5 Cantharidin has been investigated in many fields due to its powerful effects on treating tumors, pests control and --- dermatologyadvisor com cantharidin-podophyllin-salicylic-acid-treatme --- nature com articles s41598-017-02393-wPeople also askTopical cantharidin 0·7% (Ycanth) is the first treatment to be approved by the US Food and Drug Administration for the viral skin infection molluscum contagiosum Priya Venkatesan reports Molluscum contagiosum is a benign and highly contagious skin infection caused by a DNA poxvirus and characterised by small, raised lesions or papules Verrica is also developing VP-103, its second cantharidin-based product candidate, for the treatment of plantar warts The Company has also entered a worldwide license agreement with Lytix Biopharma AS to develop and commercialize VP- 315 (formerly LTX-315 and VP-LTX-315) for dermatologic oncology conditions --- tandfonline com doi full 10 1080 24750263 2023 2227655Arthropod species attracted to cantharidin (CTD) are defined as canthariphilous CTD is a toxic terpene produced as defence compound by blister beetles (Coleoptera: Meloidae) and false blister b Full article: Exploring the canthariphilous species of the Tolfa Mountains (Latium, Central Italy): taxonomic diversity, phenology, and putative sources of cantharidinWhy is cantharidin not commonly used in the United States? verrica com fda-accepts-resubmitted-filing-for-vp-102-for-the-treatment-o link springer com article 10 1007 s40272-023-00600-yTopical cantharidin in combination with podophyllotoxin and salicylic acid demonstrated efficacy for plantar warts (pediatric and adult; clearance rate range 81–100%; four studies had 100% clearance), with the majority clearing after a single treatment Satisfaction with cantharidin therapy was high, especially in molluscum contagiosum link springer com article 10 1007 s00210-022-02299-zApr 19, 2010 · Cantharidin , a potent and selective PP2A inhibitor, induces an oxidative stress‐independent growth inhibition of pancreatic cancer cells through G2 M cell‐cycle arrest and apoptosis - Li - 2010 - Cancer Science - Wiley Online Library Jan 22, 2020 · January 22, 2020 Cantharidin 1% podophyllin 2% salicylic acid 30% solution (CPS1) is a safe and promising treatment modality with high clearance and patient satisfaction rates for the management of cutaneous warts in children, according to study research published in Dermatologic Therapy In Asia, topical cantharidin was used historically for furuncles and piles, ulcers, venomous worms, and tuberculous scrofuloderma 6,7 It was used orally for abdominal masses 8 and rabies, as well as an abortifacient 9 and anticancer agent 6 In Europe, it appeared in Materia Medica, a medical monograph written by Pedanios Dioskorides in 50 to 100 AD 6 Hippocrates prescribed cantharidin as a Is cantharidin a vesicant? 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